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Engineered T Cell Therapies from a Drug Development Viewpoint Review

Fang Chen, Joseph A. Fraietta, Carl H. June, Zhongwei Xu, J. Joseph Melenhorst, Simon F. Lacey

Engineering 2019, Volume 5, Issue 1,   Pages 140-149 doi: 10.1016/j.eng.2018.11.010

Abstract: Anti-CD19 chimeric antigen receptor T cells (CART19) have demonstrated a remarkable degree of clinicalThe process of developing CART19 essentially follows the conventional “one gene, one drug, onejoining forces to commercialize this new category of “living drugs,” it is useful to use CART19constructs, preclinical studies, and the evaluation of clinical efficacy; adverse effects (AEs); and CART19We believe that the success of CART19 will lead to the development of other engineered T cell therapies

Keywords： Engineered T cell therapies     Chimeric antigen receptor     Drug development process     Biomarkers     CAR19     CART19    

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A review of the safety and efficacy of current COVID-19 vaccines

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 39-55 doi: 10.1007/s11684-021-0893-y

Abstract: Vaccination is the most effective and feasible way to contain the coronavirus disease 2019 (COVID-19)The rapid development of effective COVID-19 vaccines is an extraordinary achievement.reviewed the efficacy/effectiveness, immunogenicity, and safety profile of the 12 most progressed COVID-19

Keywords： COVID-19     SARS-CoV-2     vaccine     safety     efficacy     effectiveness     immunogenicity    

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Innovation-driven trend shaping COVID-19 vaccine development in China

Frontiers of Medicine doi: 10.1007/s11684-023-1034-6

Abstract: Confronted with the coronavirus disease 2019 (COVID-19) pandemic, China has become an asset in tacklingprotein of SARS-CoV-2 or inactivated whole virus are a cornerstone of the public health response to COVID-19

Keywords： SARS-CoV-2     COVID-19 vaccine     vaccine development    

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SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 185-195 doi: 10.1007/s11684-021-0913-y

Abstract: genomic sequence with the world, has greatly facilitated the development of coronavirus disease (COVID-19combinations and immunization strategies to provide sufficient and sustainable immune protection against COVID-19

Keywords： COVID-19     pandemics     SARS-CoV-2     vaccination    

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Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Frontiers of Medicine doi: 10.1007/s11684-023-1010-1

Abstract: Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Keywords： exosomes induce activation     impair function CD19     exosomal CD19 antigen    

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Traditional Chinese medicine for combating COVID-19

Kaixian Chen, Hongzhuan Chen

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 529-532 doi: 10.1007/s11684-020-0802-9

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Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19

Frontiers of Medicine doi: 10.1007/s11684-023-1040-8

Abstract: TCM) has played an important role in the prevention and treatment of coronavirus disease 2019 (COVID-19The integration of Chinese and Western medicine is an important feature of Chinese COVID-19 preventionFor patients with mild and moderate forms of COVID-19, TCM can relieve the related signs and symptomsFor COVID-19 patients with severe and critical illnesses, TCM can improve inflammatory indicators andA series of mechanism research studies revealed that capability of TCM to treat COVID-19 through antiviral

Keywords： traditional Chinese medicine     COVID-19     SARS-CoV-2     clinical evidence-based study     mechanism     integrated    

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Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 139-149 doi: 10.1007/s11684-021-0835-8

Abstract: The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients withmultiple trials have shown that approximately 30% of blinatumomab-relapsed cases are characterized by CD19Blinatumomab and A-319 are CD3/CD19 bispecific antibodies with different molecular sizes and structures, and A-2019 is a novel CD3/CD19/CD20 trispecific antibody with an additional anti-CD20 function., suggesting its potential function against CD19 weak or negative CD20 positive leukemic cells.

Keywords： B-cell acute lymphoblastic leukemia     bispecific antibody     trispecific antibody     CD19     CD20    

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COVID-19: why not learn from the past?

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 776-781 doi: 10.1007/s11684-021-0883-0

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Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 111-125 doi: 10.1007/s11684-021-0854-5

Abstract: The coronavirus disease 2019 (COVID-19) has spread globally.Although mixed liver impairment has been reported in COVID-19 patients, the association of liver injurycaused by specific subtype especially chronic hepatitis B (CHB) with COVID-19 has not been elucidatedmulti-center, retrospective, and observational cohort study, 109 CHB and 327 non-CHB patients with COVID-19In conclusion, COVID-19 patients with CHB were more likely to develop into severe illness and die.

Keywords： COVID-19     chronic hepatitis B     liver injury     coagulation dysfunction    

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Repercussions of COVID-19 pandemic on solid waste generation and management strategies

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1407-5

Abstract:

• Implication of COVID-19 on medical waste and MSW generation is studied

Keywords： COVID-19     Medical waste     Personal protective equipment     Municipal solid waste     Waste management    

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Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

Frontiers of Medicine doi: 10.1007/s11684-023-1044-4

Abstract: As of May 3, 2023, the coronavirus disease 2019 (COVID-19) pandemic has resulted in more than 760 millionsevere acute respiratory syndrome in 2002, the Middle East respiratory syndrome in 2012, and COVID-19of targeting IL-6 signaling to elucidate the pivotal role played by tocilizumab in combating COVID-19

Keywords： SARS-CoV-2     COVID-19     cytokine storm     interleukin-6     tocilizumab    

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Clinical characteristics of 19 neonates born to mothers with COVID-19

Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, Zhihui Rong

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 193-198 doi: 10.1007/s11684-020-0772-y

Abstract: SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19Their mothers were clinically diagnosed or laboratory-confirmed with COVID-19.There are 19 neonates included in the research.were clinically diagnosed with COVID-19.None of the neonates developed clinical, radiologic, hematologic, or biochemical evidence of COVID-19

Keywords： coronavirus disease 2019     severe acute respiratory syndrome-associated coronavirus     maternal-infant infection     newborn    

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Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 93-101 doi: 10.1007/s11684-021-0914-x

Abstract: SARS-CoV-2) via vaccination is essential to combat the current pandemic of coronavirus disease 2019 (COVID-19It has been noticed that the strength of anti-COVID-19 vaccination-induced immunity fades over time,

Keywords： COVID-19     SARS-CoV-2     vaccine     immunization     booster immunization    

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Effectiveness of inactivated COVID-19 vaccine against the severity of Omicron variant

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 576-580 doi: 10.1007/s11684-023-0991-0

Abstract: Effectiveness of inactivated COVID-19 vaccine against the severity of Omicron variant

Keywords： variant    

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Title Author Date Type Operation

Engineered T Cell Therapies from a Drug Development Viewpoint

Fang Chen, Joseph A. Fraietta, Carl H. June, Zhongwei Xu, J. Joseph Melenhorst, Simon F. Lacey

Journal Article

A review of the safety and efficacy of current COVID-19 vaccines

Journal Article

Innovation-driven trend shaping COVID-19 vaccine development in China

Journal Article

SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

Journal Article

Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Journal Article

Traditional Chinese medicine for combating COVID-19

Kaixian Chen, Hongzhuan Chen

Journal Article

Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19

Journal Article

Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific

Journal Article

COVID-19: why not learn from the past?

Journal Article

Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center

Journal Article

Repercussions of COVID-19 pandemic on solid waste generation and management strategies

Journal Article

Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

Journal Article

Clinical characteristics of 19 neonates born to mothers with COVID-19

Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, Zhihui Rong

Journal Article

Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

Journal Article

Effectiveness of inactivated COVID-19 vaccine against the severity of Omicron variant

Journal Article